TY - JOUR
T1 - The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)
AU - Rajesh, Thangavel Pichaiappa
AU - Balaji, Ramachandran
AU - Chen, Shen Ming
AU - Nivetha, Devaraj
AU - Rachel, Syam Sundar
AU - Prakash, Natarajan
AU - Steffi, Alexander Pinky
AU - Narendhar, Chandrasekar
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/3
Y1 - 2021/3
N2 - The polymer wrapped magnetic nanoparticles (Fe3O4) for the controlled release of drugs to the specific targeted site is one of the most effective way. In such a way, we have constructed a Fe3O4 magnetic nanoparticle wrapped chitosan (CS) polymer loaded with Ocimum tenuiflorum extract (phyto drug) for the drug delivery applications. The prepared composite nanomaterial is thoroughly characterized for understanding its crystal structure and surface morphology. Further, the zebra fish (Danio rerio) is chosen for the in vivo toxicity investigation of drug loaded Fe3O4/CS nanospheres. The phyto drug used has proven to have an excellent activity through our studies on zebra fish. Therefore, our designed drug loaded Fe3O4/CS nanospheres can be advocated for the real time diagnosis.
AB - The polymer wrapped magnetic nanoparticles (Fe3O4) for the controlled release of drugs to the specific targeted site is one of the most effective way. In such a way, we have constructed a Fe3O4 magnetic nanoparticle wrapped chitosan (CS) polymer loaded with Ocimum tenuiflorum extract (phyto drug) for the drug delivery applications. The prepared composite nanomaterial is thoroughly characterized for understanding its crystal structure and surface morphology. Further, the zebra fish (Danio rerio) is chosen for the in vivo toxicity investigation of drug loaded Fe3O4/CS nanospheres. The phyto drug used has proven to have an excellent activity through our studies on zebra fish. Therefore, our designed drug loaded Fe3O4/CS nanospheres can be advocated for the real time diagnosis.
KW - Chitosan
KW - Drug
KW - In vivo study
KW - Iron oxide nanoparticles
KW - Zebra fish
UR - https://www.scopus.com/pages/publications/85099263430
U2 - 10.1016/j.inoche.2021.108447
DO - 10.1016/j.inoche.2021.108447
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AN - SCOPUS:85099263430
SN - 1387-7003
VL - 125
JO - Inorganic Chemistry Communications
JF - Inorganic Chemistry Communications
M1 - 108447
ER -