Sonochemical Synthesis and Characterization of Rod-Shaped Bi₂O₃/ZnO Anchored with f-MWCNT Nanocomposite for the Electrochemical Determination of Ofloxacin

Detection of trace quantities of pharmaceutical drug ofloxacin (OFL) must be very simple and accurate. Innovative honeycomb-like structures have received considerable attention over the years due to their superior electrochemical and mechanical character. Herein, rod-shaped Bi2O3/ZnO and multiwalled carbon nanotubes were assembled to form a honeycomb structure like nanocomposite (hc-Bi2O3/ZnO:f-MWCNT). The new hc-BZM was synthesized via the cost-effective sonochemical method. A simple and convenient electrochemical determination of OFL was developed based on hc-BZM modified GCE. The physicochemical and electrochemical characterization was investigated by CV and DPV. The respective calibration curve has good linearity with current vs the concentration of OFL in the range of 0.5 to 39 μM with a correlation coefficient of R2 = 0.991. From the calibration curve slope, the detection limit and sensitivity were determined to be 0.03 μM and 1.063 μA μM-1 cm-2. The proposed sensor explained the structural advantages of simple design, low cost, wide linear range, good selectivity, and reusability. Also, the suggested hc-BZM composites can provide a new platform for the simultaneous determination of OFL, PXM, and DA. Finally, the sensor was successfully applied for the determination of OFL in human urine and serum sample, the obtained results have good agreement with added and the recovery value.