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Recrystallization of acetaminophen and sulindac from the batch and continuous supercritical anti-solvent precipitation

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摘要

Recrystallization and micronization of pharmaceuticals of acetaminophen and sulindac using supercritical anti-solvent (SAS) methods were investigated in this study. Carbon dioxide was used as the anti-solvent, and ethanol or acetone was used as the solvent. Crystalline particles were obtained from the original amorphous and irregular morphologies. Taking the acetaminophen for example, the particle size was originally up to 200 μm. It reduced to 10 to 50 μm after the batch SAS treatment, and to leb than 10 μm in the continuous SAS proceb.

原文English
主出版物標題Joint 20th AIRAPT and 43rd EHPRG International Conference on High Pressure Science and Technology
編輯Eckhard Dinjus
發行者Karlsruhe Forschungszentrum Karlsruhe gmbH
ISBN(電子)9783923704491
出版狀態Published - 2005
事件International Joint 20th AIRAPT and 43rd EHPRG International Conference on High Pressure Science and Technology - Karlsruhe, Germany
持續時間: 27 6月 20051 7月 2005

出版系列

名字Joint 20th AIRAPT and 43rd EHPRG International Conference on High Pressure Science and Technology

Conference

ConferenceInternational Joint 20th AIRAPT and 43rd EHPRG International Conference on High Pressure Science and Technology
國家/地區Germany
城市Karlsruhe
期間27/06/051/07/05

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