The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)

Thangavel Pichaiappa Rajesh; Ramachandran Balaji; Shen Ming Chen; Devaraj Nivetha; Syam Sundar Rachel; Natarajan Prakash; Alexander Pinky Steffi; Chandrasekar Narendhar

doi:10.1016/j.inoche.2021.108447

The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)

Thangavel Pichaiappa Rajesh
, Ramachandran Balaji
, Shen Ming Chen
, Devaraj Nivetha
, Syam Sundar Rachel
, Natarajan Prakash
, Alexander Pinky Steffi
, Chandrasekar Narendhar

Department of Chemical Engineering and Biotechnology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The polymer wrapped magnetic nanoparticles (Fe₃O₄) for the controlled release of drugs to the specific targeted site is one of the most effective way. In such a way, we have constructed a Fe₃O₄ magnetic nanoparticle wrapped chitosan (CS) polymer loaded with Ocimum tenuiflorum extract (phyto drug) for the drug delivery applications. The prepared composite nanomaterial is thoroughly characterized for understanding its crystal structure and surface morphology. Further, the zebra fish (Danio rerio) is chosen for the in vivo toxicity investigation of drug loaded Fe₃O₄/CS nanospheres. The phyto drug used has proven to have an excellent activity through our studies on zebra fish. Therefore, our designed drug loaded Fe₃O₄/CS nanospheres can be advocated for the real time diagnosis.

Original language	English
Article number	108447
Journal	Inorganic Chemistry Communications
Volume	125
DOIs	https://doi.org/10.1016/j.inoche.2021.108447
State	Published - Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Chitosan
Drug
In vivo study
Iron oxide nanoparticles
Zebra fish

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10.1016/j.inoche.2021.108447

Cite this

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title = "The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)",

abstract = "The polymer wrapped magnetic nanoparticles (Fe3O4) for the controlled release of drugs to the specific targeted site is one of the most effective way. In such a way, we have constructed a Fe3O4 magnetic nanoparticle wrapped chitosan (CS) polymer loaded with Ocimum tenuiflorum extract (phyto drug) for the drug delivery applications. The prepared composite nanomaterial is thoroughly characterized for understanding its crystal structure and surface morphology. Further, the zebra fish (Danio rerio) is chosen for the in vivo toxicity investigation of drug loaded Fe3O4/CS nanospheres. The phyto drug used has proven to have an excellent activity through our studies on zebra fish. Therefore, our designed drug loaded Fe3O4/CS nanospheres can be advocated for the real time diagnosis.",

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AU - Rajesh, Thangavel Pichaiappa

AU - Balaji, Ramachandran

AU - Chen, Shen Ming

AU - Nivetha, Devaraj

AU - Rachel, Syam Sundar

AU - Prakash, Natarajan

AU - Steffi, Alexander Pinky

AU - Narendhar, Chandrasekar

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AB - The polymer wrapped magnetic nanoparticles (Fe3O4) for the controlled release of drugs to the specific targeted site is one of the most effective way. In such a way, we have constructed a Fe3O4 magnetic nanoparticle wrapped chitosan (CS) polymer loaded with Ocimum tenuiflorum extract (phyto drug) for the drug delivery applications. The prepared composite nanomaterial is thoroughly characterized for understanding its crystal structure and surface morphology. Further, the zebra fish (Danio rerio) is chosen for the in vivo toxicity investigation of drug loaded Fe3O4/CS nanospheres. The phyto drug used has proven to have an excellent activity through our studies on zebra fish. Therefore, our designed drug loaded Fe3O4/CS nanospheres can be advocated for the real time diagnosis.

KW - Chitosan

KW - Drug

KW - In vivo study

KW - Iron oxide nanoparticles

KW - Zebra fish

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The iron oxide/polymer nanocomposites for targeted drug delivery and toxicity investigation on zebra fish (Danio rerio)

Abstract

Bibliographical note

Keywords

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