Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Che Chi Shu; Anushree Chatterjee; Wei Shou Hu; Doraiswami Ramkrishna

doi:10.1016/j.ces.2011.07.062

Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Che Chi Shu
, Anushree Chatterjee
, Wei Shou Hu
, Doraiswami Ramkrishna

Department of Chemical Engineering and Biotechnology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Population balance modeling is considered for cell populations in gene regulatory processes in which one or more intracellular variables undergo stochastic dynamics as determined by Ito stochastic differential equations. This paper addresses formulation and computational issues with sample applications to the spread of drug resistance among bacterial cells. It is shown that predictions from population balances can display qualitative differences from those made with single cell models which are usually encountered in the literature. Such differences are deemed to be important.

Original language	English
Pages (from-to)	188-199
Number of pages	12
Journal	Chemical Engineering Science
Volume	70
DOIs	https://doi.org/10.1016/j.ces.2011.07.062
State	Published - 5 Mar 2012

Bibliographical note

Funding Information:
The work is supported by a grant from NIH ( GM081888 ) to WSH.

Keywords

Biological and biomolecular engineering
Drug resistance transfer
Formulation
Gene regulatory processes
Mathematical modeling
Population balance

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10.1016/j.ces.2011.07.062

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abstract = "Population balance modeling is considered for cell populations in gene regulatory processes in which one or more intracellular variables undergo stochastic dynamics as determined by Ito stochastic differential equations. This paper addresses formulation and computational issues with sample applications to the spread of drug resistance among bacterial cells. It is shown that predictions from population balances can display qualitative differences from those made with single cell models which are usually encountered in the literature. Such differences are deemed to be important.",

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AU - Hu, Wei Shou

AU - Ramkrishna, Doraiswami

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KW - Biological and biomolecular engineering

KW - Drug resistance transfer

KW - Formulation

KW - Gene regulatory processes

KW - Mathematical modeling

KW - Population balance

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Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Abstract

Bibliographical note

Keywords

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