Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Chien Ho Chen; Der Zen Liu; Hsu Wei Fang; Hong Jen Liang; Tzu Sheng Yang; Shyr Yi Lin

doi:10.1271/bbb.80096

Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Chien Ho Chen
, Der Zen Liu
, Hsu Wei Fang
, Hong Jen Liang
, Tzu Sheng Yang
, Shyr Yi Lin

Department of Chemical Engineering and Biotechnology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 μg/ml of dihydrotanshinone I to AGS cell for 24 h, compared to control. Furthermore, the AGS cell survival rate for multi-target versus single target liposomal drugs was significantly suppressed. Microsocpic examination revealed that significant cell death occurred in the multi- and single-target liposomal encapsulated drug groups. Significant suppression of tumor growth in AGS cell xenograft nude mice given octreotide-PEG-liposome, RGD/octreotide-PEG-liposome encapsulated drug, versus those given a free drug was noted after 13 d of experimentation with the multi-targeted liposome: up to 60.75% and 41.2% reduction of tumor volume as compared to dimethylsulfoxide (DMSO) control and the free drug groups respectively. The treated animals showed no gross signs of toxicity. The results have potential clinical application.

Original language	English
Pages (from-to)	1586-1594
Number of pages	9
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	6
DOIs	https://doi.org/10.1271/bbb.80096
State	Published - 2008

Bibliographical note

Funding Information:
This study was supported in part by grants from Taipei Medical University and Taipei Medical University Hospital, 94TMU-TMUH-11; Council of Agriculture, Executive Yuan, Taiwan, 96-AS-1.2.1-ST-a1.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arg-Gly-Asp (RGD)
Gastric cancer
Liposome
Octreotide
Xenograft

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10.1271/bbb.80096

Cite this

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title = "Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer",

abstract = "We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 μg/ml of dihydrotanshinone I to AGS cell for 24 h, compared to control. Furthermore, the AGS cell survival rate for multi-target versus single target liposomal drugs was significantly suppressed. Microsocpic examination revealed that significant cell death occurred in the multi- and single-target liposomal encapsulated drug groups. Significant suppression of tumor growth in AGS cell xenograft nude mice given octreotide-PEG-liposome, RGD/octreotide-PEG-liposome encapsulated drug, versus those given a free drug was noted after 13 d of experimentation with the multi-targeted liposome: up to 60.75\% and 41.2\% reduction of tumor volume as compared to dimethylsulfoxide (DMSO) control and the free drug groups respectively. The treated animals showed no gross signs of toxicity. The results have potential clinical application.",

keywords = "Arg-Gly-Asp (RGD), Gastric cancer, Liposome, Octreotide, Xenograft",

author = "Chen, \{Chien Ho\} and Liu, \{Der Zen\} and Fang, \{Hsu Wei\} and Liang, \{Hong Jen\} and Yang, \{Tzu Sheng\} and Lin, \{Shyr Yi\}",

note = "Funding Information: This study was supported in part by grants from Taipei Medical University and Taipei Medical University Hospital, 94TMU-TMUH-11; Council of Agriculture, Executive Yuan, Taiwan, 96-AS-1.2.1-ST-a1.",

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AU - Chen, Chien Ho

AU - Liu, Der Zen

AU - Fang, Hsu Wei

AU - Liang, Hong Jen

AU - Yang, Tzu Sheng

AU - Lin, Shyr Yi

N1 - Funding Information: This study was supported in part by grants from Taipei Medical University and Taipei Medical University Hospital, 94TMU-TMUH-11; Council of Agriculture, Executive Yuan, Taiwan, 96-AS-1.2.1-ST-a1.

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N2 - We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 μg/ml of dihydrotanshinone I to AGS cell for 24 h, compared to control. Furthermore, the AGS cell survival rate for multi-target versus single target liposomal drugs was significantly suppressed. Microsocpic examination revealed that significant cell death occurred in the multi- and single-target liposomal encapsulated drug groups. Significant suppression of tumor growth in AGS cell xenograft nude mice given octreotide-PEG-liposome, RGD/octreotide-PEG-liposome encapsulated drug, versus those given a free drug was noted after 13 d of experimentation with the multi-targeted liposome: up to 60.75% and 41.2% reduction of tumor volume as compared to dimethylsulfoxide (DMSO) control and the free drug groups respectively. The treated animals showed no gross signs of toxicity. The results have potential clinical application.

AB - We studied the effects of multi- and single-target liposomal drugs on human gastric cancer cell AGS both in vitro and in vivo. The cytotoxic effect of dihydrotanshinone I was significantly enhanced by treatment with octreotide-polyethylene glycol(PEG)-liposome, Arg-Gly-Asp(RGD)-PEG-liposome, and RGD/octreotide-PEG-liposome encapsulated with 0.5 μg/ml of dihydrotanshinone I to AGS cell for 24 h, compared to control. Furthermore, the AGS cell survival rate for multi-target versus single target liposomal drugs was significantly suppressed. Microsocpic examination revealed that significant cell death occurred in the multi- and single-target liposomal encapsulated drug groups. Significant suppression of tumor growth in AGS cell xenograft nude mice given octreotide-PEG-liposome, RGD/octreotide-PEG-liposome encapsulated drug, versus those given a free drug was noted after 13 d of experimentation with the multi-targeted liposome: up to 60.75% and 41.2% reduction of tumor volume as compared to dimethylsulfoxide (DMSO) control and the free drug groups respectively. The treated animals showed no gross signs of toxicity. The results have potential clinical application.

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Evaluation of multi-target and single-target liposomal drugs for the treatment of gastric cancer

Abstract

Bibliographical note

UN SDGs

Keywords

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