Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation

Sheng Tung Huang; Hsien Shou Kuo; Chiao Long Hsiao; Yuh Ling Lin

doi:10.1016/S0968-0896(02)00004-4

Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation

Sheng Tung Huang
, Hsien Shou Kuo
, Chiao Long Hsiao
, Yuh Ling Lin

Department of Chemical Engineering and Biotechnology

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 μM.

Original language	English
Pages (from-to)	1947-1952
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0896(02)00004-4
State	Published - 2002

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10.1016/S0968-0896(02)00004-4

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abstract = "Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 μM.",

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AU - Lin, Yuh Ling

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AB - Series of naphthoquinone thiol-crown ethers had been prepared. The antibacterial, antifungal, and cytotoxic activities of these synthetic naphthoquinone thiol-crown ethers were investigated. All of the compounds tested displayed antibacterial, cytotoxic and antifungal activities. The bis-naphthoquinone thiol-crown ether 7a was the most potent inhibitor among tested analogues against Staphylococcus aureus methicillin resistance with MIC value of 2.68 μM.

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Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation

Abstract

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