Anti-tuberculosis drug pyrazinamide determination at multiwalled carbon nanotubes/graphene oxide hybrid composite fabricated electrode

Herein we report a simple electrochemical approach for preparing multiwalled carbon nanotubes (MWCNTs)/graphene oxide (GO) composite obtained by dispersion of MWCNTs and GO. The obtained composite modified glassy carbon electrode (GCE) has to sensitive perform for the electrochemical reduction of pyrazinamide (PZM). The surface morphological results by transmission electron microscope (TEM) confirmed that MWCNTs were enfolded with GO sheets. The chief reason for the detection of PZM at nanocomposite was the highly interaction process effect between MWCNTs and GO. The electrochemical reduction of PZM was employed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The response of PZM is linear over the concentration range from 37.5 - 1800 μM, with the detection limit (S/N = 3) of 5.54 μM and the sensitivity was found to be 0.038 μA μM^-1 cm^-2. The proposed sensor exhibits good sensitivity, selectivity and has shown potential for the detection of PZM in real samples with appreciable consistency and precision. In addition, the proposed electrochemical sensor showed good results towards the commercial pharmaceutical formulated PZM samples.